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buccal tablets of Valsartan using various suitable bioadhesive polymers such as CP 934, HPMC K4M, and Na CMC. A backing layer of ethyl cellulose was used which is impermeable in nature. Six formulations of Valsartan were prepared by direct compression method. The prepared tablets were characterized by swelling studies, % matrix erosion, surface pH, bioadhesive properties, In-vitro drug dissolution and In-vitro diffusion studies. It was found that swelling index was proportional to CP and Na CMC content. As the Na CMC content increases the swelling index also increased. The surface pH of all formulations was found to be satisfactory, and values were in between the range of 5-7 pH, hence no irritation to buccal cavity is assumed. Tablets containing CP: HPMC in the ratio 1:3 has shown maximum percentage of In-vitro drug release as well as In-vivo diffusion through buccal mucosa. The drug release was found to be zero order release. The formulation F3 was considered as the optimized formulation based on satisfactory bioadhesive strength, In-vitro dissolution drug release of 59.69 ± 0.95%, In-vitro drug diffusion of 43.66 ± 0.68% for 8 h.
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Author(s): Anup Kumar Roy Vinod kumar sm Syed Jalaluddin Basha Rabiul Haque Roopa Karki
Valsartan, Mucoadhesive Buccal Tablets,HPMC K4M, Carbopol 934.