alexa Abstract | Formulation and evaluation of pH sensitive polymeric blended microgel beads of clarithromycine for the effective treatment of Helicobacter pylori

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The objective of this investigation was to develop a pH sensitive intra gastric floating drug delivery system of clarithromycin in order to treatment of peptic ulcer disease caused by Helicobacter pylori (H. pylori). In the present investigation buoyant beads of sodium alginate, wherein, the oil was entrapped, was blended with gellan gum or pectin in order to evaluate its potential in the targeted sustained delivery of clarithromycine (Cl) in the gastric region. The formulation was developed using inotropic gelation technique using calcium carbonate as gas forming agent and further it was emulsified with mineral oil. The scanning electron microscope photograph indicated that prepared beads were spherical in shape and formulation variables such as ratio of the blended polymer, calcium carbonate effected bead size, floating and encapsulation efficiency of microbeads. The formulation exhibited sustained release profile and was best fitted in the Peppas model of drug kinetic and release exponent (n) value was more than 0.45. Coating of selected formulation exhibited zero-order sustained pattern of the Cl release up to 8 hr. In - vitro growth inhibition study of the coated beads showed good anti microbial activity against isolated H. pylori strain. The Results provides evidence that optimized gel bead may be preferred for gastro retentive controlled delivery of clarithromycine.

To read the full article Peer-reviewed Article PDF image

Author(s): Girish K Tripahi S Singh G Nath


Clarithromycine (Cl), pH sensitive drug delivery system , Gastric retention

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version