700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Research Article Open Access
The objective of this investigation was to develop a pH sensitive intra gastric floating drug delivery system of clarithromycin in order to treatment of peptic ulcer disease caused by Helicobacter pylori (H. pylori). In the present investigation buoyant beads of sodium alginate, wherein, the oil was entrapped, was blended with gellan gum or pectin in order to evaluate its potential in the targeted sustained delivery of clarithromycine (Cl) in the gastric region. The formulation was developed using inotropic gelation technique using calcium carbonate as gas forming agent and further it was emulsified with mineral oil. The scanning electron microscope photograph indicated that prepared beads were spherical in shape and formulation variables such as ratio of the blended polymer, calcium carbonate effected bead size, floating and encapsulation efficiency of microbeads. The formulation exhibited sustained release profile and was best fitted in the Peppas model of drug kinetic and release exponent (n) value was more than 0.45. Coating of selected formulation exhibited zero-order sustained pattern of the Cl release up to 8 hr. In - vitro growth inhibition study of the coated beads showed good anti microbial activity against isolated H. pylori strain. The Results provides evidence that optimized gel bead may be preferred for gastro retentive controlled delivery of clarithromycine.
To read the full article Peer-reviewed Article PDF
Author(s): Girish K Tripahi S Singh G Nath
Clarithromycine (Cl), pH sensitive drug delivery system , Gastric retention