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Original Articles Open Access
The goal of the study was to formulate pulsatile release tablets of ramipril by using a combination of core material croscarmellose sodium and coating hydrophilic polymer HPMC K100M and hydrophobic polymer ethylcellulose. Ramipril is used in the treatment of hypertension. It has a short half life (2-4 hrs). Ramipril 2.5mg pulsatile release tablets were prepared by direct compression method and evaluated for thickness, hardness, weight variation, friability, drug content and in-vitro release of drug. In-vitro drug release was carried out using USP type II apparatus at 50 rpm in 900ml of dissolution media for 7 hrs. Mean dissolution time is used to evaluate drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. Various kinetics models were applied to the dissolution profile to determine the drug release kinetics. All the physical characteristics evaluated for the tablets were obtained to be within the acceptable limits. The release profile of optimized formulation of ramipril was close to korsmeyer peppas model. Irrespective of the polymer type and its concentration, the prepared optimized pulsatile tablets showed non fickian (anomalous) release. Finally it was clear that core polymer crosscarmellose sodium and coating polymer HPMC K100M and ethyl cellulose are good candidates for preparing pulsatile tablets of ramipril.
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Author(s): Rajesh Asija Sangeeta Asija Avinash Gupta Dolly Prakashchand and Gaurav Goyal
Hypertension, In-Vitro release, Pulsatile release, Kinetics, pulsatile tablet, Medicine