alexa Abstract | Formulation and evaluation of raft forming sustained release tablet containing Ranitidine

Journal of Chemical and Pharmaceutical Research
Open Access

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Original Articles Open Access

Abstract

Now a days, acidity, heart burning and gastro esophagus reflux disease are the most common problems which is seen in the patients. So this type of the problems can be overcome by the raft forming tablets containing combination of H2 receptor blocker (Ranitidine) as well as raft forming agents (Sodium alginate and Pectin). The tablet was prepared by wet granulation method and evaluated for raft strength, raft volume, acid neutralization capacity and in vitro drug release. The highest raft strength is obtained by that tablets which are having sodium alginate and pectin in their appropriate amount. Mainly sodium alginate and pectin, a raft forming agents are playing important role in formation of raft formation. F5 batch was shown maximum raft strength, raft volume and raft weight. Same batch was shown in vitro drug release up to 5 hour. So by various evaluation test it can be conclude that raft forming tablet containing ranitidine could be an effective dosage form for treatment of peptic ulcer, heart burning, GERD (Gastro esophageal reflux).

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Author(s): Kanabar Vishvesh B and Patel Vipul P

Keywords

Ranitidine, raft forming tablet, sodium alginate, pectin, acid neutralization capacity, GRDDS, Ranitidine

 
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