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The objective of this study was to design oral sustained release matrix tablets of nicorandil using different proportion of Limonia acidissima gum as the release retardant and to study the effect of formulation factor such asin-vitro release of drug. The gum is extracted and evaluated for physico-chemical and phyto-chemical property of the gum. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density and compressibility index, showed satisfactory results. Compressed tablets were evaluated for thickness, friability, hardness, drug content, weight variation and in-vitro dissolution studies. Fourier transform infrared (FTIR) study revealed that there was no chemical interaction between drug and the gum used. All the formulation showed compliance with Pharmacopoeial standards. In-vitro drug release studies were carried out using USP 35/NF30 dissolution apparatus type II at 50 rpm (rate per minute). The release kinetics was analyzed using the zero-order, first-order model, Higuchi’s square-root equation and the Korsmeyer-peppas model. In-vitro release studies revealed that the release rate decreased with increase in gum proportion. The developed sustained release matrix tablets of nicorandil, with good initial release (15% in first hour) and extension of release for more than 12 h, can overcome the disadvantages of conventional tablets of nicorandil.
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Author(s): Vinod R
Controlled release, Limonia acidissima, Matrix tablets, Nicorandil