alexa Abstract | Formulation and evaluation of topical azelaic acid gel

Journal of Chemical and Pharmaceutical Research
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Azelaic acid, anti-acne drug has been selected havi ng very low solubility and permeability. The poor w ater solubility and permeability of azelaic acid results in difficulties in the formulation of this substan ce for topical application. Topical formulations of azelaic acid a re available in the concentration ranging from 10-2 0 % w/v. Marketed azelaic acid gel (15% w/v) improves some o f the less satisfactory properties of cream formula tions, such as their high lipid and emulsifier content, inheren t instability, sticky feel, and whitening effect, a nominally lower strength in comparison to marketed cream (20% w/v). The most frequent treatment-related cutaneous adve rse events that occurs during administration of azelaic acid g el include burning/ stinging/tingling and pruritus. Gels are considered to be the most suitable delivery vehicle for topical formulation. Use of chemical penetrati on is one of the approaches to reduce the systemic adverse effects o f topically applied drugs to enhance their permeabi lity so as to reduce the topically applied dose. Hence, our prese nt work attempted to increase its permeability and reducing side effects by using two different types of penetration enhancer i.e. from natural source i.e. piperine an d that of synthetic i.e. DMSO and their combination.

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Author(s): aideep Bajaj and Dinesh Sharma


topical azelaic acid gel, Formulation

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