alexa Abstract | Formulation and in vitro evaluation of sustained release floating matrix tablet of Rosiglitazone Maleate

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


The present study involves formulation and evaluation of sustained release floating tablet using Rosiglitazone maleate as a model anti-diabetic drug. Endeavors with respect to floating mechanism are inculcated in the formulation to achieve longer stay of tablet in stomach, which happens to the better site of absorption for the selected drug. Preformulation studies involving organoleptic, bulk density, angle of repose, tapped density, compressibility index, Hausner’s ratio, melting point range, pH and solubility were carried out as per IP specifications. Drug excipients compatibilities were carried out physical evaluation and FTIR, which showed no significant change in any way to the mixture. Different grades of HPMC viz, E4M, E15M, K100M were utilized in the trails. All the physical evaluations and preformulation studies were carried out on all the three different polymers utilized. All the formulations exhibited values within the acceptable range. Rosiglitazone tablets were evaluated for weight variations, hardness, friability, thickness, and buoyancy studies. Release studies were carried out in 0.1 N HCL, for 12 hours. Results indicated that formulation F4, gave 93.78% release up to 12 hrs, which is formulated with E15M alone. Assay was carried out for formulation F4 and was found to be 99.23%. The mechanism of drug release form matrix tablets follows Non- Fickian release (Diffusion and Swelling). Remaining formulations gave fluctuating release profiles. The formulation F4 was considered to be better among the trails accomplished.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Krishna Mohan Chinnala Rabi Narayan Panigrahy Ramesh Bantu Gowtham Reddy Kallem


Rosiglitazone, floating, anti-diabetic, FT – IR, buoyancy studies, Non-Fickian release

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us