alexa Abstract | Formulation and in-vitro evaluation gastroretentive drug delivery system of Cefixime for prolong release

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


In present research work to develop cefixime gastroretentive tablets for prolong release and increased gastric retention time. Cefixime is third generation cephalosporin antibiotic. Cefixime is slowly and incompletely absorbed from the GIT, which resulting into the poor bioavailability 40-50 %. Cefixime gastroretentive tablets were prepared by direct compression method. The powder blend was subjected for pre-compressional parameters. The prepared tablets are evaluated to post-compressional parameters. Drug compatibility with excipients was checked by DSC and FTIR studies. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. The values of post-compressional parameters evaluated were within acceptable limits. The results of buoyancy and lag time study, the values of in-vitro buoyancy time ranges from 32 to 654 min where as floating lag time ranges from 2.36 to 57 min. The formulation GRT-5 shows the lag time 2.36 min and buoyancy time 654 min. These results revealed that as the concentration of sodium bicarbonate increases there is increase in total buoyancy time and decrease in lag time. The citric acid level in the formulations greatly influenced the drug release. The release of cefixime from all the formulations in the range of 33.53 - 58.15 % at the end of 6 hrs and 58.41 - 95.34 % at the end of 12 hrs. The formulation, GRT-5 shows 58.15 % drug release in 6 hrs and 95.34 % drug release at the end of 12 hrs. DSC and FT-IR studies revealed that, there was no incompatibility of the drug with the excipients used. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. Form this study, it is concluded that, the formulation retained for longer periods of time in the stomach and provides prolong release of the drug. Hence it may increase the therapeutic efficacy of the drug by increasing the bioavailability.

To read the full article Peer-reviewed Article PDF image

Author(s): N G Raghavendra Rao Harsh A Panchal and Pentewar Ram


Cefixime, HPMC K4M, floating tablets, prolong release, bioavailability

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


busi[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version