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Research Article Open Access
The present investigation concerns the development of Hydro dynamically balanced tablets of Ciprofloxacin Hydrochloride, are designed to prolong the gastric residence time after oral administration and thereby increasing drug bioavailability. Floating tablets of Ciprofloxacin Hcl were prepared by direct compression using HPMC K4M and HPMC K15M as polymers along with Sodium bicarbonate as gas generating agent. The tablets were evaluated for in-vitro buoyancy, dissolution studies and physical characteristic viz. Density, Hardness, Friability, Thickness and Weight variation. Further, tablets were evaluated for in-vitro release characteristic for 12 hrs. It is found that the hardness of the tablets affects the Buoyancy characteristic of the dosage form. All formulations possessed good floating properties with total floating time more than 12 hrs. The in-vitro release studies indicated that the floating tablets of Ciprofloxacin Hcl containing 200mg HPMC K15M (F4) showed sustained release when compared with the marketed product and provides a better option for controlled release action and improved bioavailability.
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Author(s): UpendarraoGolla Bharath KumarNalla Rasagnya Talla Praveen KumarGajam Sandeep KumarVoore
Gastric residence, Ciprofloxacin, Buoyancy, HPMC K4M, HPMC K15M