alexa Abstract | Formulation and Invitro Evaluation of Gastroretentive Drug Delivery System of Ciprofloxacin Hydrochloride

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The present investigation concerns the development of Hydro dynamically balanced tablets of Ciprofloxacin Hydrochloride, are designed to prolong the gastric residence time after oral administration and thereby increasing drug bioavailability. Floating tablets of Ciprofloxacin Hcl were prepared by direct compression using HPMC K4M and HPMC K15M as polymers along with Sodium bicarbonate as gas generating agent. The tablets were evaluated for in-vitro buoyancy, dissolution studies and physical characteristic viz. Density, Hardness, Friability, Thickness and Weight variation. Further, tablets were evaluated for in-vitro release characteristic for 12 hrs. It is found that the hardness of the tablets affects the Buoyancy characteristic of the dosage form. All formulations possessed good floating properties with total floating time more than 12 hrs. The in-vitro release studies indicated that the floating tablets of Ciprofloxacin Hcl containing 200mg HPMC K15M (F4) showed sustained release when compared with the marketed product and provides a better option for controlled release action and improved bioavailability.

To read the full article Peer-reviewed Article PDF image

Author(s): UpendarraoGolla Bharath KumarNalla Rasagnya Talla Praveen KumarGajam Sandeep KumarVoore

Keywords

Gastric residence, Ciprofloxacin, Buoyancy, HPMC K4M, HPMC K15M

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords