alexa Abstract | Formulation and in-vitro evaluation of orodispersible tablets of olanzapine for the improvement of dissolution rate

Journal of Chemical and Pharmaceutical Research
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Abstract

The objective of this study was to formulate the orodispersible tablets (ODTs) of Olanzapine (OLZ) by direct compression method for the enhancement of dissolution rate. OLZ ODTs were prepared by direct compression method using co-processed superdisintegrants like sodium starch glycolate (SSG) and Croscarmellose sodium (CCS). It was observed from the evaluation studies that the results were complied with the official limits. In-vitro dissolution studies were carried out by USP dissolution apparatus, paddle method using pH 6.8 phosphate buffer and the formulations F8, F9 showed maximum drug release of 101.16% and 99.45% respectively within 2 min. It was evident from the drug release studies that the formulation F8 and F9 consists of CP-3 showed optimum drug release of 101.80% and 100.33% respectively.

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Author(s): S B Thirumalesh Naik Kambham Venkateswarlu and K B Chandrasekhar

Keywords

Olanzapine, Co-processed technique, Orodispersible tablets, Dissolution rate enhancement, superdisintegrants., orodispersible tablets

 
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