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Research Paper Open Access
Diltiazem hydrochloride was tried to be formulated as sustained release tablet using hydroxy propyl methyl cellulose (methocel), ethyl cellulose and Eudragit as sustaining materials in various proportions.Thus ten formulations were prepared and some of them had same amount of ingredients but they differed in hardness. One commercial sustained release tablet was compared with fabricated sustained release tablets. One fabricated tablet was found close to theoretical sustained release and commercial sustained release tablet during in vitro release characteristics. Study indicated that higher hardness slowed the release pattern in dissolution study. Hydroxy propyl methyl cellulose in the drug:polymer ratio 1:0.6 at 7.5 kg/cm2 hardness showed almost required result in present study. Successful formulation was found stable in release profile for 45 d stability study at 40Â±1Â°.
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Author(s): VP Pandey R Manavalan T Sundar Rajan KS Ganesh