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Research Article Open Access
Objective of this study was to formulate directly compressible fast disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of concentration of superdisintegrant, Ac-di-sol and directly compressible material, cellectose 80 on disintegration time was studied. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in vitro disintegrating time, wetting time and in vitro drug release. A 32 full factorial design was applied to investigate the combine effect of 2 formulation variable: directly compressible material, cellactose® 80 and Superdisintegrant, Ac-di-sol. Here the concentration of directly compressible material and concentration of superdisintegrant were taken as independent variable, X1 and X2 respectively. The effect of Disintegration time, wetting time, Q15 and friability were investigated as dependent parameters. The results of analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of superdisintegrant and a higher percentage of directly compressible material. The systematic formulation approach helped in understanding the effect of formulation processing variables.
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Author(s): Nayankumar C Ratnakar and Bhupendra G Prajapati
fast disintegrating tablet, Cinnarizine, 32 factorial design, cellactose® 80, Ac-di-sol