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Direct compression is a simplest, time saving and economical way of tablets’ manufacturing. It is just a mixing and compression of dry blend of powder. The aim of study is to prepare caffeine tablets (200 mg) by direct compression. Three formulations F1, F2 and F3were prepared, containing different combinations of Avicel and DiTab, keeping the amount of drug and magnesium stearate constant. Micromeritic properties of blend and powders were determined, including carr’s index, hausner ratio, angle of repose and particle distribution analysis. Different compendial and non- compendial tests were performed to assess the quality of directly compressible tablets. F2was an optimized product as it is superior in terms of better weight variation, hardness, percent release (99.02%) and assay (100.02%).On the basis of results it is concluded that the caffeine tablets could be satisfactorily produced by direct compression.
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Author(s): Kamran AlamHuma ShareefRabia Bushra
Caffeine, Tablets, Direct Compression, Stability testing, Formulation Development