alexa Abstract | Formulation Development and Characterization of Modified Release Microspheres of Antianginal Drug

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Ranolazine (RZ) is an antiischemic/antianginal agent employed in therapy of cardiovascular diseases such as myocardial infarction, variant and exercise-induced angina and arrhythmias constipation, headache, nausea and dizziness are the most common side effects. So the aim of the present research work was to formulation development and characterization of modified release RZ loaded EC microspheres by o/w emulsion solvent diffusion evaporation technique with different ratio of drug and ethyl cellulose as a polymer in order to achieve high entrapment efficiency and prolonged release characteristics. The prepared microspheres were characterized by Scanning electron microscopy (SEM), percent yield, micrometrics properties, Fourier transformer infra red spectroscopy (FTIR), percent entrapment efficiency and percent drug release characteristics. The size of microspheres formulations (F1 to F6) were in range of 20±1.2 to 54±1.7μm, percent yield 78.21±2.31 to 94.24±1.21%, percent drug entrapment efficiency 53.25±0.65 to 85.76±0.78% and percent drug release 56.87 ± 0.34 to 92.74 ± 0.83 % up to 12 hrs. IR study showed no interaction between drug and polymer; no degradation during microspheres preparation and stable at storage conditions. All microsphere formulations showed various drug releases kinetic but F2 formulation followed first order drug release kinetics and 92.74 ± 0.83% drug release for prong period of time. From the study, it was investigated that free flowing spherical microspheres of RZ could be prepared successfully by solvent diffusion evaporation technique with high entrapment efficiency and prolong release profile characteristics.

To read the full article Peer-reviewed Article PDF image

Author(s): Gupta Jitendra Mohan Govind Prabakaran L Gupta Reena


Ranolazine, Ethyl Cellulose, Anti-ischemic/Anti-anginal

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version