alexa Abstract | Formulation development and evaluation of Emtricitabine and Tenofovir Disproxil Fumarate Tablets

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Emtricitabine and Tenofovir disproxil fumarate belongs to class of anti-retroviral drugs known as nucleotide analogue reverse transcriptase inhibitors. The main objective of the present study is to formulate and evaluate an immediate release tablet of Emtricitabine and Tenofovir disproxil fumarate using different disintegrants. Preformulation studies were performed prior to compression. The tablets were compressed using microcrystalline cellulose, lactose, pregelatinized starch, croscarmellose sodium, talc, sodium starch glycolate, magnesium stearate and opadry II blue was used for coating the tablets. The fabricated tablets were evaluated for various micromeritic properties like bulk density, tapped density, compressibility index, Hausner’s ratio, angle of repose and post compression characteristics like thickness, hardness, friability, disintegration time and drug release. Croscarmellose sodium is found to be the better disintegrant when compared to sodium starch glycolate in the formulation of immediate release tablets of Emtricitabine and Tenofovir disproxil fumarate. Compared to the direct compression, wet granulation with pregelatinized starch as binder was found to be the best method of choice for formulation of these tablets. The absorbance of Emtricitabine and Tenofovir disproxil fumarate were screened in the UV region and the maximum absorbance was found to be 282 nm and 258nm respectively and this was used for HPLC analysis. The results of the present study indicates that, the prepared tablets of Emtricitabine and Tenofovir disproxil fumarate could perform therapeutically, with improved efficacy and better patient compliance like that of the marketed product.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Manikandan M Kannan K Selvamuthukumar S Manavalan R

Keywords

Emtricitabine, Tenofovir disproxil fumarate, Antiretroviral, immediate release tablets.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords