Research Article Open Access
Cefuroxime axetil is an oral antibacterial prodrug of cephalosporin antibiotic, cefuroxime. It is used frequently for
pediatric conditions like upper respiratory tract infections. The bitter taste of Cefuroxime axetil greatly hinders the
further development of suitable formulations of this drug for oral use. Hence, it is important to mask the bitter taste
and also to make them suitable for oral use. Lubritab is used as a taste masking agent. The taste masked dry
suspension was made by compaction process. The prepared suspension was evaluated for various parameters like
sedimentation volume, degree of flocculation, drug content and In-vitro dissolution profile. All the parameters were
found to be within limits. When the results were also compared with marketed formulation, the prepared suspension
was found to be better with respect to marketed preparation.
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Author(s): J Vinod and A Chenthilnathan
Cefuroxime axetil, Taste masking, Lubritab, Dry suspension.