alexa Formulation, Development and Optimization of Fast Dissolving Oral Film of Montelukast Sodium | Abstract

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Introduction: The current research in the field of drug delivery by which fast release can be achieved has been intensified. The present study was an attempt to develop and evaluate an oral fast dissolving drug delivery system using Musa paradisiaca powder as a novel superdisintegrant. Materials and methods: The formulation contains a model drug (Montelukast sodium), a novel superdisintegrant (Musa paradisiaca powder) and film former (HPMC E15 LV) and the fast release effect was achieved with the proper combination of film former and superdisintegrant. A 32 full factorial design was employed for the optimization of developed formulation considering concentration of superdisintegrant and concentration of film former as independent variables with drug release and disintegration time as dependent variables. Results and discussion: The effect of varying concentrations of the independent variables, HPMC E15 LV and Musa paradisiaca powder on the dependent variables was studied. It was found that enhancing the polymer concentration shows negative effect on disintegration time and the drug release. But when the concentration of the Musa paradisiaca powder was increased, it had a positive impact on the disintegration time and drug release. Conclusion: It can be concluded that addition of Musa paradisiaca powder to the formulation helps to achieve a fast release of drug and hence may help in rapid onset of action that may lead to improved oral bioavailability of drug.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Rahul A Jain and Atish S Mundada

Keywords

Fast dissolving oral film, Montelukast sodium, Musa paradisiaca powder, Solvent casting technique, Antimicrobial Drug Development, Herbal Drug Development

 
OMICS International Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version