alexa Abstract | Formulation, evaluation and stability study of sennoside A & B capsule

Journal of Chemical and Pharmaceutical Research
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Abstract

The objective of research work was to evaluate and perform stability study of prepared and developed S ennoside A and B capsule. The Sennoside A and B capsule was s uccessfully develop by adding optimum necessary act ive ingredient and all the prepared formulations were evaluated by different methods such as HPLC and dis solution study Moreover, stability study was performed as pe r ICH guidelines. All five formulations were identi fied by chromatogram of HPLC as well as performing dissolut ion and disintegration study. In addition to, organ oleptic qualitative and quantitative evaluation of calcium sennoside was carried by consideration of its pH, l oss on drying, tapped density, ash value and its assay. The result s obtained in this research work clearly indicated that out of all five formulation, formulation IV significantly incr eased the frequency and wet weight of stools to 31. 5 ± 4.25 and 8.29 ± 1.21 g, and showed tendency to increase the frequency and wet weight of stools. The frequency a nd the wet weight of stools following gum arabic for 14 days w ere 16.3±3.98 and 4.79±1.14 g respectivel

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Author(s): Sagar Jadav P V Habbu Rashmi Vanakudri Ashish Patel and Kirtan Sanghvi

Keywords

Sennoside capsule, Formulation, ICH, Stability study, Formulation, sennoside

 
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