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Research Article Open Access
The present investigation was aimed to formulate and optimize the trannsdermal patch of carvedilol by using the combination of HPMC K100M, HPMC E5, PVA, Eudragit RL100, oleic acid and propylene glycol. Formulation optimization of transdermal patch was done by using 32 factorial design and by response surface methodology. The formulations were evaluated for thickness, tensile strength, folding endurance, drug content, MVT in 24 hr, moisture content. The values for these were practically acceptable. The in vitro permeation studies showed higher permeation of carvedilol with permeation rate ranges from 0.964 to 1.616 mg/cm2/ hr. The kinetic treatment of permeation data reveals zero-order drug release. Stability studies of the optimized batch at 25 ± 2°C, 4°C and 45 ± 2°C showed no significant alteration in drug content.
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Author(s): Shashikant D Barhate and Mrugendra B Potdar
Transdermal patch, HPMC K100M, HPMC E5, PVA, Eudragit RL100