alexa Abstract | Formulation, Physico-chemical characterization and Release kinetic study of antihypertensive Transdermal Patches

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The objective of the present study was to develop the matrix type transdermal patches of Carvedilol Phosphate (CP) using polymeric combination of polyvinylpyrrolidone (PVP) and ethylcellulose (EC) by solvent casting method over a backing membrane of polyvinylalcohol. All the prepared formulations were subjected to physicochemical studies like drug content, thickness, weight variation, moisture content, moisture uptake, water vapor transmission, flatness and folding endurance. The drug-polymer compatibility was ascertained by Fourier Transform Infrared spectroscopy (FTIR). The surface morphology and drug distribution in the patch was studied by Scanning Electron Microscopy (SEM). The release profile of the drug was evaluated by in-vitro dissolution study in 6-stage USP dissolution apparatusII, and in-vitro permeability study was done in 6 stage diffusion cell apparatus (FDC-06, Orchid Scientifics, Nashik) through dialysis membrane-70(LA 393, Hi Media). The results of physicochemical studies indicate the suitability of patch formulation of CP with the polymeric combinations of PVP and EC. The in-vitro drug release and permeation studies indicate that the required rate of drug release can be adjusted by selecting proper ratio of PVP and EC. Highest correlation was observed with Higuchi plot rather than first order or zero order. The present study has demonstrated the potential of the fabricated matrix transdermal patches of CP for sustained delivery through transdermal route.

To read the full article Peer-reviewed Article PDF image

Author(s): Pintu K De Jibitesh Paul Sanjoy K Dey Subas C Dinda Soumen Rakshit

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords