alexa Abstract | Ganglionectomy in the adult male rat increases neuronal size and synaptic density in remaining contralateral major pelvic ganglion

Current Neurobiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

This study aimed to characterize ganglion hypertrophy in the major pelvic ganglion (MPG) of male rats after contralateral ganglionectomy. Eighteen adult male Sprague-Dawley rats were used in this study. Nine of them were subjected to long-term (6 weeks) contralateral ganglionectomy, and nine were used as a control group. Six weeks postoperatively, the ani-mals were euthanized and the MPG was identified and removed completely with its acces-sory ganglia and the associated nerves. The ganglia were then studied at the light micro-scope level using acetylcholinesterase histochemistry and synaptophysin immunohistochem-istry, and at the ultrastructural level using transmission electron microscopy. To assess the size of ganglionic neurons, morphometric analysis was done at the light microscope level of sections of resin-embedded pelvic ganglia. No shift was found in location of remaining gan-glion after contralateral ganglionectomy. The remaining ganglion was larger and more elongated dorso-ventrally. Morphometric analysis done using semi-thin and thin sections revealed an increase in the neuronal size and expansion of synaptic connections of the con-tralateral ganglionectomy over the control, but there was no evidence of increased neournal number following contralateral ganglionectomy, despite the fact that it was found that after few weeks post contralateral ganglionectomy the remaining ganglion extended its innerva-tions to cover the opposite side which was innervated by the excised ganglion. We demon-strated the occurrence of hypertrophy in the neurons of the pelvic ganglion in the adult male rats, and that this hyperatrophy was a result of increase in neuronal size rather than number. This study has paved the way for investigating the mechanisms underlying neu-ronal hypertrophy, such as the role of cellular signaling processes and neurotrophic factors involved in pelvic neuron plasticity.

To read the full article Peer-reviewed Article PDF image

Author(s): Abdullah Aldahmash and Muhammad Atteya

Keywords

Ganglionectomy, major pelvic ganglion, neuronal hypertrophy, neuronal plasticity

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords