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Short Communication Open Access
Petroleum ether extract of Caesalpinia pulcherrima was examined in HCl/ethanol and aspirin and pylorus ligation models in the rat. Pretreatment of the extract prevented the formation of gastric lesions in HCl/ethanol model. In aspirin and pylorus ligation model, the extract was able to significantly reduce the ulcer score and increase in mucus content, but had no effect on gastric juice volume or acid content. Thus the results indicate that the extracts' antiulcerogenic effect is attributable to augmentation of gastric defense mechanisms.
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Author(s): Anil Kumar V Nirmala