alexa Gene Expression Monitoring in Pediatric Heart Transplant Recipients | Abstract

Insights in Pediatric Cardiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Background: AlloMap® gene expression testing is a non-invasive screening tool approved for use in heart transplant recipients age 15 and older. Experience with AlloMap® in pediatric heart transplant recipients is limited. We sought to describe the variations in AlloMap® scores seen in pediatric heart transplant recipients.
Methods and Findings: This is a retrospective study of all pediatric heart transplant recipients with AlloMap® scoring at a single institution between 2013 and 2014. All possible scores were recorded. Other variables recorded at the time of each AlloMap® score included immunosuppressive regimen, patient demographics and endomyocardial biopsy (EMB) results. Patients were excluded if they had undergone other solid or multi-solid organ transplantation. Onehundred AlloMap® scores were available from 42 patients, with a median age at transplantation of 4.3 years. The median AlloMap® score for all patients was 32 (IQR, 30-35). Of the 100 AlloMap® scores, 10% were collected in patients <2 years, 41% in 2-12 years and 49% were >12 years of age. There was little difference in the median score between age groups (p=0.143). Forty-five scores had a concomitant biopsy. Twenty-eight (62%) patients had ISHLT grade 0 and 16 (36%) had ISHLT grade 1 rejection. AlloMap® scores were higher in patients with evidence of ISHLT grade 1 acute cellular rejection (ACR) on EMB (p=0.044). AlloMap® scores were similar across all immunosuppression regimens (p=0.403), with TAC+MMF (n=43) and TAC+SIR (n=27) being the most commonly used regimens. In patients with multiple AlloMap® readings, the median change in AlloMap® score from baseline reading was 2 (IQR, 2-5) without significant change on biopsy findings.
Conclusions: In pediatric heart transplant recipients, AlloMap® scores were higher in patients with ISHLT grade 1 rejection than in patients with ISHLT grade 0 rejection. AlloMap® scores did not appear to be affected by patient age or immunosuppression regimen. Further studies should be performed to confirm the findings of this study and determine the place for AlloMap® in post-transplant monitoring of pediatric patients.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Courtney Sutton Ryan Butts Ali Burnette Andrew Savage Walter Uber and A Lauren Haney

Keywords

Pediatric heart transplant, Gene expression, Immunosuppressive

 
OMICS International Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version