alexa Abstract | Gene Therapy in Lung Transplantation

Electronic Journal of Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Lung transplantation is a well-accepted life-saving treatment for end-stage lung diseases. However, the short-term and long-term success of lung transplantation is hindered by multiple factors such as the shortage of organ donors, primary graft dysfunction, life-long immunosuppression and chronic graft dysfunction. Gene transfection presents a potential molecular therapeutic solution to these problems by genetically modifying the transplanted organ. Experimental studies have demonstrated that gene therapy in lung transplantation is more effectively conducted by intra-airway delivery of adenoviral vector to donor lungs in vivo. Immunosuppression routinely used in clinical lung transplantation helps to enhance the efficacy and duration of desired gene expression. Transfection of interleukin-10 is the best studied and most promising strategy to attenuate ischemia-reperfusion injury, which is a major contributor to primary graft dysfunction. Modulation of local immune response is another interesting strategy of IL-10 gene therapy in lung transplantation, which might improve long-term outcome of lung transplantation. In this article, we present a brief review in gene therapy in lung transplantation and perspective of future directions in the field.

To read the full article Peer-reviewed Article PDF image

Author(s): Masaaki Sato Shaf Keshavjee Mingyao Liu

Keywords

Gene therapy, Lung transplantation, Interleukin-10

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us