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The effects of steroidal and non-steroidal contraceptive oral pill on haematological parameters were studied in wistar female albino rats for 30 days. The steroidal combined oral contraceptive pill (norgestrel + ethinylestradiol) was diluted to 0.14 mg/ ml (Low Dose), 0.21 mg/ml (dose as per literature), and 0.43 mg/ ml (high dose). The non-steroidal oral contraceptive pill (Centchroman) was diluted to 0.29 mg/ ml (Low Dose), 0.43 mg/ml (dose as per literature) and 0.87 mg/ml (high dose). The result shows a reduction in Red blood cell (RBC) and White blood cell (WBC) counts in all the groups that were given steroidal combined oral pill (ethinylestradiol + norgestrel) and non-steroidal oral pill (Centchroman), compared to the controls in each group. The reduction of RBC, WBC and Lymphocytes was found in steroidal combined oral pill (ethinylestradiol + norgestrel). In the present investigation a dose of 0.43 mg/ ml (high dose )and 0.87 mg/ml (high dose) has more reduction in Red blood cell (RBC) and White blood cell (WBC) counts as compare to other groups. The changes in haematological parameters all the groups treated with norgestrel + ethinylestradiol as well as Centchroman indicating some adverse effects on the rats. More research is needed to calculate the perfect dose which will not lead to any adverse effect.
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Author(s): MP Chikhale
Steroidal and non-steroidal, Contraceptive oral pill, Haematological parameters, Female wistar albino, physiology, cell and molecular biology, genetics, biochemistry, biotechnology, bioinformatics, microbiology, immunology, parasitology, endocrinology