alexa Abstract | Hematological changes induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats: Alleviating effect of vitamin C

Der Pharmacia Sinica
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Research Article Open Access

Abstract

Lead and chlorpyrifos (CPF) are among the most pervasive environmental contaminants that adversely affect human and animal health. Oxidative stress is a common molecular mechanism implicated in lead and CPF poisoning. The present study was aimed at evaluating the ameliorative effect of vitamin C on hematological changes induced by subchronic coadministration of CPF and lead in Wistar rats. Forty adult male Wistar rats were divided into 4 groups of 10 animals in each group. Group I was corn oil (2 ml/kg) while group II was administered vitamin C only (100 mg/kg). Group III was co-administered with CPF(4.25 mg/kg) and lead (250 mg/kg). The regimens were administered once daily by gavage for a period of nine weeks. The rats were sacrificed at the end of the dosing period and blood samples were analyzed for hematological parameters. The study revealed that alterations in pack cell volume, erythrocyte indices, and concentrations of hemoglobin, red blood cells, erythrocyte malonaldehyde, platelets, and absolute total and differential white blood cells induced by subchronic co-administration of CPF and lead were ameliorated by vitamin C. The attenuation of this hemotoxicity by vitamin C may be partly due to its antioxidant properties.

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Author(s): Suleiman F Ambali Mary Angani Muftau Shittu and Mohammed U Kawu

Keywords

chlorpyrifos, lead, co-administration, hemotoxicity, oxidative stress, vitamin C

 
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