alexa Abstract | Hematological changes induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats: Alleviating effect of vitamin C

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Lead and chlorpyrifos (CPF) are among the most pervasive environmental contaminants that adversely affect human and animal health. Oxidative stress is a common molecular mechanism implicated in lead and CPF poisoning. The present study was aimed at evaluating the ameliorative effect of vitamin C on hematological changes induced by subchronic coadministration of CPF and lead in Wistar rats. Forty adult male Wistar rats were divided into 4 groups of 10 animals in each group. Group I was corn oil (2 ml/kg) while group II was administered vitamin C only (100 mg/kg). Group III was co-administered with CPF(4.25 mg/kg) and lead (250 mg/kg). The regimens were administered once daily by gavage for a period of nine weeks. The rats were sacrificed at the end of the dosing period and blood samples were analyzed for hematological parameters. The study revealed that alterations in pack cell volume, erythrocyte indices, and concentrations of hemoglobin, red blood cells, erythrocyte malonaldehyde, platelets, and absolute total and differential white blood cells induced by subchronic co-administration of CPF and lead were ameliorated by vitamin C. The attenuation of this hemotoxicity by vitamin C may be partly due to its antioxidant properties.

To read the full article Peer-reviewed Article PDF image

Author(s): Suleiman F Ambali Mary Angani Muftau Shittu and Mohammed U Kawu


chlorpyrifos, lead, co-administration, hemotoxicity, oxidative stress, vitamin C

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version