alexa Abstract | Hepatitis C Virus and Human T-cell Lymphotropic Virus Coinfection: A Epidemiological, Clinical and Laboratory Analysis

Archives of Clinical Microbiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Background: Hepatitis C is the principal cause of chronic liver disease. In Brazil, statistics show that 2.5 million individuals are infected with HTLV-I, representing in absolute terms the largest number of individuals in the world infected by this virus. Data from the literature suggest that HTLV infection exerts a detrimental effect on cell immune response, exacerbates the progression of hepatitis C and negatively affects treatment response in HCV co-infected patients. The objective of this study is to describe epidemiological, clinical and laboratory characteristics of a group of patients co-infected with both hepatitis C virus (HCV) and human T-cell lymphotropic virus (HTLV) and another with HCV monoinfected patients. Methods: Anti-HTLV I/II ELISA was performed in HCV-RNA-positive patients of Gaffrée and Guinle Teaching Hospital (HUGG) Outpatient Hepatology Department, followed by Western blot and/or PCR for confirmation. Groups of co and monoinfected individuals were submitted to epidemiological analysis and to clinical and laboratory evaluation: hematological, biochemical, HCV genotype, HCV viral load and liver fibrosis score. Statistical analysis was performed using the SPSS statistical software program, version 16.0. For comparison between the groups of study, p-values and their respective 95% confidence intervals were calculated using the Fisher´s exact test or Mann-Whitney´s test. Results: The seroprevalence of HCV/HTLV co-infection was 7.4% (95%CI: 4.5-11.6%; n=16/215). A control group of 83 HCV monoinfected individuals was constituted. Most participants in the two groups were male, white and symptomless. Intravenous drug abuse was more common in co-infected than in monoinfected individuals (33.3% versus 10.8%; p=0.037). Advanced liver fibrosis (Metavir fibrosis score ≥ 2) was more common in monoinfected patients (59.3% versus 10%; p=0.005), as were elevated levels of ALT (p=0.030), AST (p=0.015) and GGT (p=0.055). Conclusions: Contrary to the literature, this study found no clinical, biochemical or histological differences between HCV/HTLV coinfected patients compared to HCV monoinfected patients.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Alessandra Mendona de Almeida Maciel Carlos Eduardo Brando Mello

Keywords

Hepatitis C, HTLV, Co-infection, Epidemiological, Clinical, Laboratory analysis, Brazil, Mycobacterial Diseases, Bacterial Infection

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords