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The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of Eichhornia crassipes against CCl4 induced albino rats. The methanolic extract of E. crassipes (500 mg/kg) was administered orally to the animals with hepatotoxicity induced by CCl4 (1 ml /kg). Silymarin (100 mg/kg) was given as reference standard. The plant extract was effective in protecting the liver against the injury induced by CCl4 in rats. This was evident from significant reduction in serum glutamic-pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP) and bilirubin. It was concluded from the result that the methanolic extract of E. crassipes possesses hepatoprotective activity against CCl4 induced hepatotoxicity in rats.
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Author(s): G Dineshkumar R Rajakumar P Mani and TMM Johnbastin
E. crassipes, CCl4, hepatoprotetive, hepatotoxicity., physiology, cell and molecular biology, genetics, biochemistry, biotechnology, bioinformatics, microbiology, immunology, parasitology