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Research Paper Open Access
Ethanol extract of Piper longum fruits and five different crude fractions, petroleum ether (40-60Â°), solvent ether, ethyl acetate, butanol and butanone were subjected to preliminary qualitative chemical investigations. The ethanolic extract and all other fractions were screened orally for hepatoprotective activity in adult Wistar rats. The ethanolic extract and butanol fraction have shown significant activity, lowering the serum enzymes glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in rats treated with carbon tetrachloride when compared to control and Liv-52-treated rats.
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Author(s): SS Jalalpure MB Patil NS Prakash K Hemalata FV Manvi