alexa Abstract | Hibiscus Rosa Sinensis alleviates Thioacetamide induced Acute Hepatotoxicity in Wistar Rats

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The plant phenolic compounds such as flavonoids play an important role in the protection of several disorders. Some of the plant derived compounds possess potent hepatoprotective efficacy. The present study was designed to assess the prophylactic effect of Hibiscus rosa sinensis (HRS) extract against thioacetamide (TAA) induced hepatotoxicity in male wistar rats. TAA treated showed noticeable hepatotoxicity symptoms marked by suppression of antioxidant armoury and destruction of liver morphology. It resulted in an elevation of serum hepatotoxicity markers such as aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase activity. However, oral pretreatment with HRS at lower (100 mg/kg b.wt.) and higher dose (200 mg/kg b.wt.), was given to rats for 14 consecutive days, showed significant reduction in the activity of enzymes viz; catalase, xanthine oxidase, glutathione peroxidase, glutathione reductase, quinone reductase and in the levels of reduced glutathione. Moreover, HRS extract significantly ameliorated TAA mediated liver injury possibly by inhibition of lipid peroxidation, restoration of endogenous enzymatic defense system and effective in preventing the development of hepatotoxicity. Histopathological examination also revealed marked recovery in pretreated groups. The protective effects of the extract could be due to the presence of polyphenolic content. Quercetin being one of its major components therefore the protective effect may be attributed on the quercetin as well as its synergistic effect with other polyphenols. The results indicate the antioxidant properties of HRS extract against TAA induced biochemical alterations.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Sana Nafees Shiekh Tanveer Ahmad Wani Arjumand Nemat Ali Summya Rashid and SarwatSultana

Keywords

Flavonoids, Prophylactic, Thioacetamide

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us