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Research Paper Open Access
High performance liquid chromatographic determination of oxymetazoline hydrochloride from nasal drops.
A reversed-phase HPLC assay procedure for the determination of oxymetazoline hydrochloride and its dosage forms is described. The compound was chromatographed on a C18 column using a mobile phase consisting of methanol: acentonitrile: water : diethylamine (45:20:35:0.3). The low values of standard deviation and coefficient of variation indicate good precision of the proposed method. The percentage recovery being 100 +/- 2 percent indicates non-interference from other excipients present in the formulations.