alexa Abstract | High Performance Thin Layer Chromatographic Analysis of Paracetamol and Etodolac in Combined Tablet Dosage Form

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

A new simple, accurate, and precise densitometric method for determination of Paracetamol and Etodolac in combined tablet dosage form has been developed and validated. Separation of the drugs was carried out using Toluene: Ethyl acetate: Methanol (5:4:1, v/v/v) as mobile phase on precoated Silica gel 60 F254 plates. The retention factors for Paracetamol and Etodolac were found to be 0.38 ± 0.02 and 0.57 ± 0.02, respectively. The densitometric evaluation of bands was carried out at 234 nm. The calibration curve was linear in the concentration range 100 to 600 ng/ band for both the drugs. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The (%) assay (Mean ± S.D.) was found to be 99.60 ± 0.76 for Paracetamol and 99.88 ± 0.58 for Etodolac, respectively. The method was validated with respect to linearity, accuracy, precision and robustness as per the International Conference on Harmonisation (ICH) guidelines. The method can be used for routine analysis of these drugs in combined tablet dosage forms in quality-control laboratories.

To read the full article Peer-reviewed Article PDF image

Author(s): Veena G Kulkarni Santosh V Gandhi Padmanabh B Deshpande Poorva Divekar

Keywords

Paracetamol, Etodolac, Silica gel, Densitometry, Tablet dosage form., High Performance Thin Layer Chromatographic

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords