alexa Abstract | High performance thin layer chromatographic estimation of lansoprazole and domperidone in tablets

Indian Journal of Pharmaceutical Sciences
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A simple, fast, precise and accurate high performance thin layer chromatographic method has been developed for the simultaneous estimation of lansoprazole and domperidone in tablet formulations. This method allows the determination of 100-500 ng/spot of lansoprazole and 100-500 ng/spot of domperidone. The mobile phase composition was n-butanol:glacial acetic acid:water (9.3:0.25:0.5, v/v/v). Densitometric analysis of lansoprazole and domperidone was carried out in the absorbance mode at 288 nm. The R f values of lansoprazole and domperidone were found to be 0.78 and 0.21 respectively. The limit of detection for lansoprazole and domperidone were found to be 10 and 30 ng/spot, respectively. The limit of quantification for lansoprazole and domperidone were found to be 40 and 65 ng/spot, respectively. The amounts of drug present in the tablet and recovery studies were also carried out. The method was validated for precision, accuracy and reproducibility.

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Author(s): JV Susheel M Lekha TK Ravi

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