alexa Abstract | High performance thin layer chromatographic method for simultaneous estimation of paracetamol and valdecoxib in tablet dosage form

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication Open Access


A new simple, sensitive and precise high performance thin layer chromatographic method has been developed for estimation of paracetamol and valdecoxib simultaneously from a combined dosage form. In this method pre coated silica gel 60 GF 254 TLC plate was used as stationary phase and the chromatogram was developed using chloroform: isopropyl alcohol: glacial acetic acid (9.5:1:0.2 v/v/v) as mobile phase. Paracetamol and valdecoxib showed Rf values 0.14±0.01 and 0.51±0.03, respectively. The plate was scanned and quantified at 250 nm using Camag TLC Scanner. The linear concentration was 2.5 to 12.5 µg/spot for paracetamol and 0.1 to 0.5 µg/spot for valdecoxib. The %RSD of intra day variation was 0.18±0.01 for paracetamol and 0.24±0.01 for valdecoxib. For inter day variation the %RSD was 0.03±0.005 and 0.1±0.02 for paracetamol and valdecoxib, respectively.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): M Gandhimathi TK Ravi Nilima Shukla G Sowmiya

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version