alexa Abstract | HIV-specific CD8+T lymphocyte responses in HIV/HCV co-infected patients

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Human immunodeficiency virus/hepatitis C virus (HIV/HCV) co-infection is still a worldwide problem. CD8+ T lymphocytes are essential in the immune system to suppress viral and infected cells. The aim of this study was to compare HIV-specific CD8+T lymphocyte responses in HIV/HCV co-infected and HIV mono-infected patients. Three groups of 23 patients were recruited from Chulalongkorn Hospital. Eleven patients were HIV mono-infected, eight were HIV mono-infected (they received GPO-VIR), and four patients were HIV/HCV co-infected. IFN gamma secreting CD8+T lymphocytes to the HIV-1 Gag and Env peptides were measured using an ELISpot assay. To determine the levels of Granzyme A, Granzyme B and perforin, all samples were measured using flow cytometry. The results showed that there was a significant decrease in the level of HIV-1 Env-specific CD8+ T lymphocytes in the HIV/HCV co-infected patients. This study found that patients with HIV/HCV co-infection have a slightly lower specific CD8+ T lymphocytes response compared with other HIV and HCV patients.



Author(s): Kaewboon B and Ammaranond P

Keywords

HIV/HCV co-infection, CD8+ T lymphocyte, ELISpot, HIV,CD8,T lymphocyte

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords