alexa Abstract | Host-guest complexes of baicalein and silybin with C-hexylpyrogallol[4]arene: Determination of the stoichiometry and the mode of binding

Journal of Chemical and Pharmaceutical Research
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Abstract

Apart from the trapping of metal ions by the various calixarenes, C-Hexylpyrogallol[4]arenes are studied for their host–guest interactions with the organic guest molecules. In this article, we report the host–guest association of a flavone, baicalein and a chromanone, silybin with C-Hexylpyrogallol[4]arene. The stoichiometry for the inclusion of these guest molecules with C-Hexylpyrogallol[4]arene is determined as 1:1 ratio by Benesi–Hildebrand equation. The strength and mode of binding of baicalein and silybin with is supported by time-resolved fluorescence, nuclear magnetic resonance correlation spectroscopic techniques and molecular docking studies. The structure of the inclusion complex is proposed.

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Author(s): Chandrasekaran Sowrirajan Israel V M V Enoch and Murugesh Easwaran

Keywords

Baicalein, Silybin, C-Hexylpyrogallol[4]arene, host–guest complex, molecular docking, stoichiometry

 
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