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Original Articles Open Access
The possible formation of a host-guest complex between levodopa and HP-β-CD was studied accordingly. A simple phase-solubility study was conducted based on the method proposed by Higuchi and Connors. The complexation constant (Kc) calculated was 30.53 M-1. An improved solubilty of levodopa was achieved as a result of complex formation with HP-β-CD. From the 1H-NMR data, upfield shifts in all HP-β-CD protons were observed. In particular, we found that Δδ H3 > Δδ H5 and this finding suggests that partial inclusion has been formed between levodopa and HP-β-CD. SEM images revealed distinct morphological images between the starting materials and the complex. Our data were all in great agreement which evidenced the formation of HP-β-CD/levodopa.
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Author(s): Zarif Mohamed Sofiana Jafri Malin Abdullahad Norshazrin Shazira Shafeea Hasnah Othmanb and Shariza Abdul Razakc
Levodopa, cyclodextrin, complex, complex