alexa Abstract | Identification of Forced Degradation Products of Itopride by LC-PDA and LC-MS

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

Degradation products of itopride formed under different forced conditions have been identified using LC-PDA and LC-MS techniques. Itopride was subjected to forced degradation under the conditions of hydrolysis, photolysis, oxidation, dry and wet heat, in accordance with the International Conference on Harmonization. The stress solutions were chromatographed on reversed phase C18 (250×4.6 mm, 5 μm) column with a mobile phase methanol:water (55:45, v/v) at a detection wavelength of 215 nm. Itopride degraded in acid, alkali and oxidative stress conditions. The stability indicating method was developed and validated. The degradation pathway of the drug to products II-VIII is proposed.

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Author(s): Payal Joshi Suvarna Bhoir AM Bhagwat K Vishwanath RK Jadhav

Keywords

Degradation products, forced degradation, itopride, stability indicating, validation

 
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