alexa Abstract | Immunohistochemical GRP78 as a tumor biomarker may predict poor prognosis in patients with non-small cell lung cancers: a retrospective study.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Purpose: To examine the correlation of GRP78 and GRP94 protein levels with clinicopathological variables and prognosis in primary Non-Small Cell Lung Cancer (NSCLC) patients.

Methods: A total of 89 primary patients with NSCLC were included. Their surgically-resected tissues were studied by immunohistochemistry to assess GRP78 and GRP94 expression. Student's t-test, Kaplan-Meier estimator with log rank test and Cox regression analyses were performed to examine the associations of GRP78/GRP94 levels with clinicopathological variables and survival.

Results: GRP78 and GRP94 expressions increased significantly in tumor samples of NSCLC patients. High GRP78 positive was associated with pathologic TNM status (p=0.003) and pathologic N status (p=0.013); while high GRP94 positive was associated with squamous-cell carcinoma subtype (p=0.001). There is no correlation between GRP78 and GRP94 levels (p =0.086). Various levels of GRP78 proteins were associated with survival of NSCLC patients (p = 0.016). A higher GRP78 level marked a shorter survival time (p = 0.043). Various levels of GRP94 proteins were not associated with survival of NSCLC patients (p = 0.610).

Conclusions: High expression of GRP78 can be related to a poor prognosis. Expression level of GRP78 protein may be a potential predictor for NSCLC prognosis.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): DuJuan Yu YunGang Luo GuoMin Liu


GRP78, GRP94, NSCLC, Immunohistochemistry, Prognosis, Predictor, #

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version