alexa Abstract | Improvement in binding affinity of Ginkgolide B in comparison to Levodopa: A molecular docking Studyc

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Parkinson’s disease involves the malfunction and death of vital nerve cells in the brain called neuron which produce dopamine, a chemical that sends message to the part of the brain that controls movement and coordination. As Parkinson’s disease progresses, the amount of dopamine produced in the brain decreases, leaving a person unable to control movement normally. The test drug Ginkgolide B and standard drug Levodopa have targeted the protein D2 receptor (PDB ID: 2YOU) and protein D3 receptor (PDB ID: 3PBL) respectively. Both the test and standard drug were drawn using Chemsketch draw software and structures were optimized using Arguslab software. Then they were docked with the Dopamine D2 protein (PDB ID: 2YOU) and Dopamine D3 protein (PDB ID: 3PBL) using HEX software. The test drug showed improvement in binding affinity and other properties in comparison to standard drug.

To read the full article Peer-reviewed Article PDF image

Author(s): Rumpa Banerjee Riya Adhya and Abhimanyu Thakur

Keywords

Parkinson’s disease, 2YOU, 3PBL, Hex docking, Chemsketch, Levodopa

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords