alexa Abstract | Improvement of dissolution rate of diacerein using liquisolid technique

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The aim of this study to investigate the use of liquisolid technique in improving the dissolution profiles of diacerein in a solid dosage form. This study was designed to improve the dissolution rate of diacerein using liquisolid technique. The liquisolid systems were formulated with PEG 400 as non-volatile liquid vehicle at three different drug concentrations, 40, 45 and 50 % W/W using two different carrier/coating ratio (5 and 10). The empirical method as introduced by spireas and Bolton was applied (1999) strictly to calculate the amounts of carrier and coating materials required to prepare diacerein liquisolid capsules. Quality control tests i.e. disintegration test, drug content and in vitro dissolution test were performed to evaluate each batch of prepared capsules. In vitro dissolution profiles of the liquisolid formulation were studied and compared with conventional formulation. DSC, FTIR and XRD were used to investigate physicochemical interaction between diacerein and the excipients. It was found that liquisolid capsules formulated with PEG 400 at lower drug concentration (40% W/W) produced high dissolution profile than conventional formulation. DSC and XRD revealed that drug particles in liquisolid formulations were completely solubilized and available in the molecularly dispersed state. In conclusion, the liquid vehicle used within diacerein liquisolid formulations enhanced drug dissolution rate.

To read the full article Peer-reviewed Article PDF image

Author(s): J Padmapreetha and K S G Arulkumaran

Keywords

Diacerein, Liquisolid, PEG 400, Liquisolid capsule, Dissolution, liquisolid technique

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us