alexa Abstract | In silico approach of antibacterial compounds from mangrove - Avicennia marina through docking analysis.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The term “In - silico” mean “any biological experiment on or in computer”. This method is easy, relatively fast and used to predict pharmacology and/or toxicology hypothesis. In - silico software have been employed in the discovery and optimization of novel bioactive compounds with affinity to a particular target, the clarification of absorption, distribution, metabolism, excretion and toxicity properties (ADME/Tox) as well as physicochemical characterization. Urinary tract infection (UTI) is a condition in which the urinary tract is infected with a patho-gen causing inflammation which is a widespread, difficult and rarely life threatening condition. Avicennia marina contains biologically active antibacterial, antiviral and antifungal compounds. Hence the antibacterial com-pounds of A. marina such as beta humulene, taraxasterol, alpha amyrin, venlafaxine, 3-(3-methoxy phenyl) pro-panoic acid and methyl 2-methylinden-3-on carboxylate were selected for this study. The docking was performed between ligands and virulent proteins of UTI pathogens, thus LIBDOCK score were analyzed, followed by Lipinski’s rule of 5 were calculated. Drug like properties of these ligands were calculated by ADME calculations. Based on these results, out of 6 compounds 2 were confirmed as promising compounds against the particular pathogens. Therefore the present study play a guiding role to develop new inhibitors with better binding affinities towards the specific virulent protein of pathogens, followed by invention of novel drug to treat UTI.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Sheela Devi A Joseph J Johanna Rajkumar

Keywords

Avicennia marina, drug discovery, mangrove plant, molecular docking, urinary tract infection, #

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords