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Original Articles Open Access
Traditional Chinese medicine has been in use till date for the treatment of various diseases including diabetes. In this study, the binding affinity of bioactive compounds derived from Chinese medicine Jinqi Jiangtang Tablet (JQJTT) against different molecular targets, were analyzed using in silico docking method. The compound that forms best protein-ligand complex is identified, as these regulatory enzymes are said to play a vital role in therapeutic action of diabetes mellitus. The bioactive compounds of JQJTT was docked with the said molecular targets using Patch Dock. The complex binding interactions of various compounds was determined by their Atomic Contact Energy (ACE). The stronger binding affinity denotes strong inhibitory action of JQJTT antidiabetic compounds against the corresponding enzymes respectively. The result of the current study clearly indicates JQJTT compounds have potent antidiabetic activity. This study elucidates the use of in-silico docking for the identification of a potent antidiabetic drug.
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Author(s): D Sathya Prabhu and V Devi Rajeswari
In silico, Patch Dock, Diabetes mellitus, Traditional Chinese Medicine, Jinqi Jiangtang Tablet, In Silico docking analysis