alexa Abstract | In Silico Interaction Studies on Inhibitory Action of endophytic fungal Diketopiperazine and its related compounds on Heat-Shock Protein 90 (Hsp90)

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

In silico interaction studies of twenty diketopiperazines (DKPs) that include the endophytic fungal diketopiperazine; hexahydropyrrollo[1,2-a]pyrazine-1,4-dione and its related compounds were screened against the cancer protein Hsp90 using Autodock Vina. The docking scores indicate that of the compounds screened, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione was most potent with docking score of -7.5 Kcal/mol. This value was better than the standard drugs; Geldanamycin, 17-(Allylamino) Geldanamycin and Alvespimycin (17DMAG). Therefore, this study recommends the consideration of Diketopiperazines for further in vitro and in vivo studies towards its development as anticancer drug.

To read the full article Peer-reviewed Article PDF image

Author(s): Sharma R Vijaya Kumar BS

Keywords

Endophytic fungal, Diketopiperazine, Hsp90, Docking score

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords