700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
In silico interaction studies of twenty diketopiperazines (DKPs) that include the endophytic fungal diketopiperazine; hexahydropyrrollo[1,2-a]pyrazine-1,4-dione and its related compounds were screened against the cancer protein Hsp90 using Autodock Vina. The docking scores indicate that of the compounds screened, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione was most potent with docking score of -7.5 Kcal/mol. This value was better than the standard drugs; Geldanamycin, 17-(Allylamino) Geldanamycin and Alvespimycin (17DMAG). Therefore, this study recommends the consideration of Diketopiperazines for further in vitro and in vivo studies towards its development as anticancer drug.
To read the full article Peer-reviewed Article PDF
Author(s): Sharma R Vijaya Kumar BS
Endophytic fungal, Diketopiperazine, Hsp90, Docking score