alexa Abstract | In vitro and in vivo advantage of celecoxib surface solid dispersion and dosage form development

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


Celecoxib surface solid dispersions were prepared by various techniques using different ratios of drug and carriers. Infra-red spectroscopy and differential scanning calorimetry showed no significant change in solid state of celecoxib in the surface solid dispersions and physical mixtures of celecoxib and carriers. Surface solid dispersions exhibited superior dissolution profiles and improved antiinflammatory activity in rat paw oedema model. The increase in the dissolution rate and consequent enhancement of antiinflammatory effect in rats of celecoxib were attributed to reduced particle size of celecoxib deposited on the surface of carrier and enhanced wettability of the drug particles brought about by the carrier. Improved dissolution characteristics were retained when compressed into tablets.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): RP Dixit MS Nagarsenker

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version