alexa Abstract | In vitro antiviral activity of some novel isatin derivatives against HCV and SARS-CoV viruses

Indian Journal of Pharmaceutical Sciences
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Abstract

4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 µg/ml, without toxicity at a concentration up to 42 µg/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.

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Author(s): P Selvam N Murgesh M Chandramohan E De Clercq E Keyaerts L Vijgen P Maes J Neyts MV Ranst

Keywords

Isatin, HCV, SARS-CoV, vero cells, huh 5-2 cells, Isatin, HCV, SARS-CoV, vero cells, huh 5-2 cells

 
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