alexa Abstract | In Vitro evaluation of domperidone mouth dissolving tablets

Indian Journal of Pharmaceutical Sciences
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Abstract

In the present research work mouth dissolving tablets of domperidone were developed with superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycollate in various concentrations like 3%, 4% and 6% w/w by direct compression method. All formulations were evaluated for physical characteristics of compressed tablets such as weight variation, hardness, friability, content uniformity, in vitro disintegration time, wetting time and in vitro dissolution study. Among all, the formulation F3 (containing 6% w/w concentration of crospovidone) was considered to be the best formulation, having disintegration time of 9 s, wetting time of 15 s and in vitro drug release of 99.22% in 15 min.

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Author(s): S Patra R Sahoo RK Panda K Himasankar BB Barik

Keywords

Crospovidone, domperidone, mouth dissolving tablets, superdisintegrants, croscarmellose sodium, sodium starch glycollate

 
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