700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Review Article Open Access
Dissolution test is an important quality control tool, provided it is based on a meaningful in vitro in vivo correlation (IVIVC). Such dissolution test can prove as a surrogate to the extensive, expensive and time consuming in vivo bioavailability testing on humans. This review discusses what are the IVIVCs and different levels of IVIVCs, and encompasses various approaches to seek meaningful IVIVCs, mainly for oral solid dosage forms. Discussed are different modifications in in vitro dissolution testing to simulate the in vivo environment, to which the formulation is subjected to after oral administration. IVIVCs with high quality and predictability can substantiate such in vitro dissolution tests, espqcially, to guide development of new modified release formulations of drugs with narrow therapeutic window. It also assesses the lot-to-lot quality of the drug product to ensure product safety and efficacy.
To read the full article Peer-reviewed Article PDF
Author(s): C J Shishoo S S Savale S A Shah I S Rathod