alexa Abstract | In Vitro Study to determine the effect of zinc on non-heme iron absorption

International Journal of Collaborative Research on Internal Medicine & Public Health
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


It has been well documented that bioavailability of iron is influenced by other food constituents. We carried out a kinetic study to look at the effect of zinc on ferric iron uptake in human epithelial Caco-2 TC7 cell-line. Zinc reduced iron uptake in a concentration-dependent manner. Iron uptake was significantly increased in the presence of ascorbic acid in the medium. We also found that zinc significantly increased the main iron transporter Divalent Metal Transporter-1 (DMT1) expression in whole cell and membrane proteins. The evidence from in vitro studies show that zinc suppressed iron uptake by Caco-2 cells and this phenomenon could be reversed by the presence of ascorbic acid in the growth media.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Aswir Abd Rashed


Iron uptake, Caco-2 TC& cells, Zinc, Ascorbic acid, Ferric iron

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version