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3-Methycholanthrene, a potent polycyclic aromatic carcinogen, induces the activities of Phase I and Phase II drug metabolism enzymes in the body. Increase in the activities of Cytochrome P-450, a most important Phase I enzyme, by 3-Methylcholanthrene in liver and kidney tissues are well established. However the effect of this aromatic carcinogen on non-cytochrome mediated drug metabolizing enzymes-renal xanthine oxidase and Glutathione-s-transferase in renal tissues is still not clear. In the present investigation it is found that intraperitonal administration of 0.25 ml of 3-Methylcholanthrene significantly elevates the activities of xanthine oxidase (p< 0.05) and Glutathione-s-transferase (p<0.05) activities in the kidney tissues. From the present study it can be concluded that like liver tissues, kidney tissues are highly modulated by the administration of xenobiotics and carcinogens. This finding can be of significant therapeutic, toxicological and pharmacological importance.
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Author(s): Acharjee BK Mahanta R
3-Methylcholanthrene (3-MC), Xanthine Oxidase (XO),Glutathione-s-transferase (GST), Kidney tissues, Xenobiotics